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Twenty-Six Years of Hell: An ME/CFS/FM Recovery Story

Infections and other stressors have been implicated in the development of fibromyalgia. Research by Pridgen and Duffy highlights that these stressors could result in recurrent reactivations of latent herpes virus infections, which could lead to the development of fibromyalgia.

This study evaluated a famciclovir + celecoxib drug combination (IMC-1), active against suspected herpes virus reactivation and infection, for the treatment of fibromyalgia.

The FDA fast tracked IMC-1, a combination of famciclovir, a common antiviral, and celecoxib, an anti-inflammatory arthritis drug, in early 2016 for a phase 3 trial, but progress has moved at a slug’s pace since then.

For the past two and a half years, IMC-1 has undergone animal studies as required by the FDA to determine potential toxicity.

IMC-1’s parent company Innovative Med Concepts is currently seeking $30 million from investors to fund the phase 3 human study. If successful, the trial should finally start early next year, according to Dr. William “Skip” Pridgen, the drug combo’s discoverer.

As a gastrointestinal surgeon, Pridgen is an unlikely source for the next blockbuster fibromyalgia drug. However, his drug combo of an antiviral and an anti-inflammatory addresses a theory that many in the fibromyalgia community have suspected for a long time: Fibromyalgia could be caused by some sort of underlying infection.

In Pridgen’s case, he believes fibromyalgia is triggered by the herpes simplex virus (HSV). IMC-1 works by combining famciclovir and celecoxib, both of which have antiviral properties, to suppress HSV.

Pridgen says he’s successfully used the drug combo in his Tuscaloosa, Alabama, medical practice for years now.

“We’ve treated thousands of patients with this protocol, and every single day I get to witness exactly what this medication does,” Pridgen says. “Once you suppress the virus, it takes [about 12 to 14 weeks] for the immune system to reset and for the body to feel normal. We’re seeing about 90 percent of the patients will get 85 percent better if they follow the protocol precisely.”

The next part of the trial is anticipated to involve between 250 to 500 patients at up to 50 sites around the country.

Twenty-Six Years of Hell: An ME/CFS/FM Recovery Story

https://www.researchgate.net/publication/314253282_A_famciclovir_celecoxib_combination_treatment_is_safe_and_efficacious_in_the_treatment_of_fibromyalgia/fulltext/5af72f510f7e9b026bd577ee/314253282_A_famciclovir_celecoxib_combination_treatment_is_safe_and_efficacious_in_the_treatment_of_fibromyalgia.pdf?origin=publication_detail https://www.healthrising.org/blog/2017/12/18/26-years-chronic-fatigue-fibromyalgia-recovery-story/